Amphetamine-induced rotation in normal cats.

Amphetamine elicited dose-related rotation (circling behavior) in 9 naive cats; all cats also rotated, at lower rates, during non-drug sessions. The direction of rotation was consistent for each cat, with 6 cats rotating to the right and 3 to the left. The results extend the generality of previous findings involving rodents and suggest that an endogenous asymmetry in striatal dopamine activity may be a common characteristic of many animal species.