猫黑质后 pars（SNPP）损伤后的药物诱导刻板行为和不对称行为。

Drug-induced stereotypes and asymmetric behaviour after substantia nigra pars posterior (SNPP) lesions in cats.

作者信息

Wolfarth S, Coelle E F, Osborne N N, Sontag K H, Wand P

出版信息

Brain Res. 1979 Dec 14;178(2-3):545-54. doi: 10.1016/0006-8993(79)90713-3.

Abstract

Apomorphine- (Apo) and amphetamine- (Amph) induced behavioural phenomena were studied in cats which received either 6-hydroxydopamine (6-OHDA) or electrothermic lesions of the posterior part of the substantia nigra (SNPP). In this species, as in rats, both drugs evoked sterotypies (sniffing and head nodding) and an enhancement of locomotor activity. However, distinct differences between the reactions of cats and rats to both drugs were found, the most evident effect being the lack of sterotyped gnawing and licking. By correlating the data on behaviour, the histological examination showing the size and location of the lesions, and the dopamine (DA) content of the corresponding caudate nuclei, it is concluded that the fewer DA-specific neurons lesioned in the SNPP, the more pronounced was the ipsilateral asymmetric behaviour. We suggest, therefore, that the ipsilateral asymmetric behaviour in cats following APO- and AMPH-treatment is due to the destruction of a non-catecholaminergic output.

摘要

在接受了6-羟基多巴胺（6-OHDA）或黑质后部（SNPP）电热损伤的猫身上，研究了阿扑吗啡（Apo）和苯丙胺（Amph）诱发的行为现象。在这个物种中，和大鼠一样，这两种药物都会诱发刻板行为（嗅探和点头）并增强运动活性。然而，发现猫和大鼠对这两种药物的反应存在明显差异，最明显的影响是缺乏刻板的啃咬和舔舐行为。通过将行为数据、显示损伤大小和位置的组织学检查以及相应尾状核的多巴胺（DA）含量相关联，得出结论：SNPP中受损的DA特异性神经元越少，同侧不对称行为就越明显。因此，我们认为，APO和AMPH治疗后猫的同侧不对称行为是由于非儿茶酚胺能输出的破坏。