Schlechte J, Vangilder J, Sherman B
J Clin Endocrinol Metab. 1981 Apr;52(4):785-9. doi: 10.1210/jcem-52-4-785.
Sixty-seven women who underwent transsphenoidal resection of PRL-secreting pituitary adenomas between 1976 and 1979 were separated into categories according to the manner of their clinical presentation. Forty-one had oral contraceptive-related onset of amenorrhea-galactorrhea, 5 had pregnancy-related onset of amenorrhea-galactorrhea, 5 had primary amenorrhea, and 16 had the spontaneous onset of amenorrhea-galactorrhea unrelated to estrogen use. Surgical success, defined as the resumption of regular menses and normalization of serum PRL concentration, was achieved in 54% of those with estrogen-related onset of amenorrhea-galactorrhea compared with 19% in the other group. The analysis of multiple preoperative features, including clinical classification, age, preoperative PRL concentration, and duration of amenorrhea-galactorrhea by logistic regression, demonstrated that the clinical classification was the most important factor in predicting the outcome of transsphenoidal surgery. It should be a prime consideration in the selection of therapy for PRL-secreting adenomas.
1976年至1979年间接受经蝶窦切除泌乳素分泌型垂体腺瘤的67名女性，根据其临床表现方式进行分类。41名女性因口服避孕药出现闭经-溢乳，5名因怀孕出现闭经-溢乳，5名有原发性闭经，16名有与雌激素使用无关的自发性闭经-溢乳。手术成功定义为恢复规律月经和血清泌乳素浓度正常化，与雌激素相关闭经-溢乳组的54%相比，其他组的成功率为19%。通过逻辑回归分析多个术前特征，包括临床分类、年龄、术前泌乳素浓度和闭经-溢乳持续时间，结果表明临床分类是预测经蝶窦手术结果的最重要因素。在选择泌乳素分泌型腺瘤的治疗方法时，应将其作为首要考虑因素。
