Gomita Y, Ueki S
J Pharmacobiodyn. 1980 Feb;3(2):94-104. doi: 10.1248/bpb1978.3.94.
Effects of olfactory bulbectomy, and lesions of the septum and dorsal hippocampus on emotionality as well as on the simple conditioned avoidance response in a two-way shuttle box were investigated in rats. The rats with bilateral olfactory bulbectomy (O. B. rats) showed hyperactivity and aggressive behavior, including mouse-killing behavior (muricide), and those with septal lesions exhibited hyperreactivity and hypoactivity, while the rats with hippocampal lesions became hypoactive without showing hyperreactivity. The O. B. and septal rats, on an average, showed a facilitation in acquisition of the conditioned avoidance response and a retardation in extinction. The muricidal group of O. B. rats, however, showed slower acquisition, while the nonmuricidal O. B. rats showed much faster acquisition and slower extinction than intact rats. Hippocampal lesions retarded acquisition.
研究了大鼠嗅球切除、隔膜损伤和背侧海马损伤对情绪以及在双向穿梭箱中简单条件性回避反应的影响。双侧嗅球切除的大鼠（嗅球切除大鼠）表现出多动和攻击行为，包括杀鼠行为（杀鼠），隔膜损伤的大鼠表现出反应过度和活动减退，而海马损伤的大鼠活动减退但无反应过度。平均而言，嗅球切除大鼠和隔膜损伤大鼠在条件性回避反应的习得方面表现出促进作用，在消退方面表现出延迟。然而，杀鼠的嗅球切除大鼠组习得较慢，而非杀鼠的嗅球切除大鼠比完整大鼠习得快得多且消退慢。海马损伤会延迟习得。
