Pritchett-Corning Kathleen R, Chang Fon T, Festing Michael F W
Research Models and Services, Charles River, Wilmington, MA, USA.
J Am Assoc Lab Anim Sci. 2009 Sep;48(5):492-8.
Few data exist regarding the effects of long-term housing of rats and mice in the same secondary enclosure. Historical reproductive and growth data were compared for colonies of mice and rats maintained in open-topped cages in either single-species or dual-species barrier rooms. This analysis included reproductive parameters (litter size at birth, litter size at weaning, and pups missing at weaning) collected from 33 colonies of mice comprising 500 to 38,500 breeding females and 28 colonies of rats totaling 350 to 4,600 breeding females, and representative samples from 28 colonies of each species were analyzed for weight gain from weaning to adulthood. The presence or absence of the other species was not associated with statistically significant differences in weight gain or any of the reproductive parameters. These results suggest that breeding colonies of rats and mice of the same health status can be housed in the same room without a negative effect on the growth and reproduction of either species.
关于大鼠和小鼠长期饲养在同一个二级饲养环境中的影响，现有数据很少。对饲养在开放式笼子里的小鼠和大鼠群体的历史繁殖和生长数据进行了比较，这些群体饲养在单物种或双物种屏障房间中。该分析包括从33个小鼠群体（包含500至38500只繁殖雌鼠）和28个大鼠群体（共计350至4600只繁殖雌鼠）收集的繁殖参数（出生时的窝仔数、断奶时的窝仔数以及断奶时缺失的幼崽数），并且对每个物种28个群体的代表性样本进行了从断奶到成年的体重增加分析。另一个物种的存在与否与体重增加或任何繁殖参数的统计学显著差异无关。这些结果表明，健康状况相同的大鼠和小鼠繁殖群体可以饲养在同一个房间，而不会对任何一个物种的生长和繁殖产生负面影响。
