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The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins.

作者信息

Gozukara E M, Belvedere G, Robinson R C, Deutsch J, Coon M J, Guengerich F P, Gelboin H V

出版信息

Mol Pharmacol. 1981 Jan;19(1):153-61.

PMID:7193798
Abstract
摘要

相似文献

1
The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins.环氧化物水解酶对苯并[a]芘二醇环氧化物水解及与DNA和混合功能氧化酶蛋白结合的影响。
Mol Pharmacol. 1981 Jan;19(1):153-61.
2
Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.苯并[a]芘二醇环氧化物：酶促形成机制及光学活性中间体
Science. 1977 Jun 10;196(4295):1199-201. doi: 10.1126/science.870975.
3
Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes.
Biochem Pharmacol. 1976 Oct 1;25(19):2221-5. doi: 10.1016/0006-2952(76)90138-6.
4
Drug detoxification: epoxide hydrolase.药物解毒：环氧水解酶。
Prog Clin Biol Res. 1983;135:81-105.
5
The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity.环氧水合酶诱导剂反式氧化茋可将苯并(a)芘的代谢环氧化作用从湾区转移至K区，并降低其致突变性。
Mol Pharmacol. 1979 Sep;16(2):656-66.
6
Enzymatic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives.苯并[a]芘转化为酚类和二醇的酶促机制及苯并[a]芘衍生物的改进高效液相色谱分离
Biochemistry. 1977 Aug 9;16(16):3680-7. doi: 10.1021/bi00635a027.
7
Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.通过产物形成以及与DNA的结合所显示的各种纯化形式的细胞色素P-450在苯并[a]芘和（-）反式-7,8-二羟基-7,8-二氢苯并[a]芘代谢中的区域选择性和立体选择性。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3123-7. doi: 10.1073/pnas.75.7.3123.
8
Effect of purified epoxide hydrolase on metabolic activation and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway.纯化环氧水解酶对苯并(a)芘代谢活化及与外源DNA结合的影响。活化途径的转变。
Biochem Biophys Res Commun. 1980 Mar 28;93(2):611-6. doi: 10.1016/0006-291x(80)91122-5.
9
Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.与诱变代谢物控制相关的激活和失活酶的物种差异。
Arch Toxicol. 1977 Dec 30;39(1-2):97-108. doi: 10.1007/BF00343279.
10
Transplacental induction of mixed-function oxygenases in extra-hepatic tissues by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochem Pharmacol. 1977 Aug 1;26(15):1383-8. doi: 10.1016/0006-2952(77)90361-6.

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Contributions of human enzymes in carcinogen metabolism.人类酶在致癌物代谢中的作用。
Chem Res Toxicol. 2012 Jul 16;25(7):1316-83. doi: 10.1021/tx300132k. Epub 2012 May 10.
2
ATP-dependent transport of glutathione conjugate of 7beta, 8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene in murine hepatic canalicular plasma membrane vesicles.7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并[a]芘谷胱甘肽共轭物在小鼠肝小管质膜囊泡中的ATP依赖性转运
Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):799-805. doi: 10.1042/bj3320799.
3
Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at level of protein and mRNA.
大鼠和人肝脏胞质环氧化物水解酶：蛋白质和mRNA水平上多种形式的证据。
Environ Health Perspect. 1990 Aug;88:49-55. doi: 10.1289/ehp.908849.