Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes.

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作者信息

Yang S K, Gelboin H V

出版信息

Biochem Pharmacol. 1976 Oct 1;25(19):2221-5. doi: 10.1016/0006-2952(76)90138-6.

DOI:10.1016/0006-2952(76)90138-6

PMID:971337

Abstract

摘要

相似文献

Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes.

Biochem Pharmacol. 1976 Oct 1;25(19):2221-5. doi: 10.1016/0006-2952(76)90138-6.

Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.苯并[a]芘二醇环氧化物：酶促形成机制及光学活性中间体

Science. 1977 Jun 10;196(4295):1199-201. doi: 10.1126/science.870975.

Enzymatic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives.苯并[a]芘转化为酚类和二醇的酶促机制及苯并[a]芘衍生物的改进高效液相色谱分离

Biochemistry. 1977 Aug 9;16(16):3680-7. doi: 10.1021/bi00635a027.

Kinetic behaviour of microsomal styrene monooxygenase and styrene epoxide hydratase in different animal species.不同动物物种中微粒体苯乙烯单加氧酶和苯乙烯环氧化物水合酶的动力学行为。

Experientia. 1977 Jun 15;33(6):708-9. doi: 10.1007/BF01944141.

Transplacental control of epoxide hydratase and its relationship to the control of microsomal monooxygenase.环氧化物水解酶的胎盘转运调控及其与微粒体单加氧酶调控的关系。

FEBS Lett. 1975 May 1;53(2):205-10. doi: 10.1016/0014-5793(75)80020-2.

The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins.环氧化物水解酶对苯并[a]芘二醇环氧化物水解及与DNA和混合功能氧化酶蛋白结合的影响。

Mol Pharmacol. 1981 Jan;19(1):153-61.

Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

J Biol Chem. 1977 Sep 25;252(18):6328-34.

Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide.针对均一环氧水解酶的抗体为一种可水化氧化苯乙烯和苯并(a)芘4,5-氧化物的单一酶提供了证据。

Nature. 1976;259(5538):53-5. doi: 10.1038/259053a0.

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.苯并(a)芘的酶促转化主要通过单一异构体的r-7,t-8-二羟基-7,8-二氢苯并(a)芘生成二醇环氧化物r-7,t-8-二羟基-t-9,10-氧基-7,8,9,10-四氢苯并(a)芘。

Proc Natl Acad Sci U S A. 1976 Aug;73(8):2594-8. doi: 10.1073/pnas.73.8.2594.

A rapid assay for epoxide hydratase activity with benzo (a)pyrene 4,5-(K-region)-oxide as substrate.以苯并（a）芘4,5-（K区）氧化物为底物的环氧水解酶活性快速检测法。

Anal Biochem. 1976 Jul;74(1):94-104. doi: 10.1016/0003-2697(76)90312-2.

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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.非对映体苯并[a]芘7,8 - 二醇 - 9,10 - 环氧化物光学对映体在新生小鼠中的致瘤性：(+)-7β,8α - 二羟基 - 9α,10α - 环氧 - 7,8,9,10 - 四氢苯并[a]芘的异常活性

Proc Natl Acad Sci U S A. 1978 Nov;75(11):5358-61. doi: 10.1073/pnas.75.11.5358.

Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.通过产物形成以及与DNA的结合所显示的各种纯化形式的细胞色素P-450在苯并[a]芘和（-）反式-7,8-二羟基-7,8-二氢苯并[a]芘代谢中的区域选择性和立体选择性。

Proc Natl Acad Sci U S A. 1978 Jul;75(7):3123-7. doi: 10.1073/pnas.75.7.3123.

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