[维生素B1、硫胺素焦磷酸和黄素腺嘌呤二核苷酸对平滑肌细胞的作用机制]
[Mechanism of action of vitamin B1, thiamine pyrophosphate, and FAD on smooth muscle cells].
作者信息
Romanenko A V, Khalmuradov A G, Shuba M F
出版信息
Ukr Biokhim Zh (1978). 1981 Jan-Feb;53(1):76-8.
The contractile activity of the guinea pig taenia coli longitudinal muscle was studied as affected by exogenic thiamine, thiamine pyrophosphate and FAD. The mentioned substances in a concentration of 1 . 10(-3) M relax the smooth-muscular cells. Against a background of apamine FAD causes a contraction of taenia coli, which is not observed with application of thiaminepyrophosphate. Evidently, there are two, types of receptors sensitive to FAD and one sensitive to vitamin B1 on the membrane of the smooth-muscular cell.
研究了外源性硫胺素、硫胺素焦磷酸和黄素腺嘌呤二核苷酸（FAD）对豚鼠结肠带纵行肌收缩活性的影响。上述物质浓度为1. 10（-3）M时可使平滑肌细胞舒张。在蜂毒明肽的背景下，FAD可引起结肠带收缩，而硫胺素焦磷酸则不会引起这种现象。显然，平滑肌细胞膜上存在两种对FAD敏感的受体和一种对维生素B1敏感的受体。
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