Nilsson B, Nilsson I M, Hedner U
Acta Med Scand. 1981;209(1-2):45-9. doi: 10.1111/j.0954-6820.1981.tb11550.x.
In a study of 21 patients with recurrent venous thrombosis and/or thrombophlebitis, fibrinolytic activity measured after venous occlusion was significantly improved after treatment with 6 mg delta 4-ethylestrenol (Orgabolin) daily. Seven of the 21 patients had abnormally low vessel wall plasminogen activator content, which normalised during treatment. No tendency to develop resistance to the drug was observed during treatment for periods up to 56 months. This improvement was shown to be combined with a significant lower (p less than 0.001) incidence of thrombosis.
在一项针对21例复发性静脉血栓形成和/或血栓性静脉炎患者的研究中，每日服用6毫克δ4-乙基雌烯醇（奥加保林）治疗后，静脉闭塞后测得的纤溶活性显著改善。21例患者中有7例血管壁纤溶酶原激活物含量异常低，治疗期间恢复正常。在长达56个月的治疗期间，未观察到对该药物产生耐药性的趋势。这种改善与血栓形成的发生率显著降低（p<0.001）相关。
