Kjaeldgaard A, Kjaeldgaard M
J Clin Pathol. 1986 Nov;39(11):1241-4. doi: 10.1136/jcp.39.11.1241.
The effect of adrenaline on plasminogen activator release was studied in vitro in human vein biopsy specimens, in which the fibrinolytic activity was determined according to the fibrin slide technique. The tissue slides were covered with a thin fibrin film containing 10(-9) and 10(-7) M adrenaline and exposed for 30 to 60 minutes. In both concentrations highly significant (p less than 0.001) enhancement of fibrinolytic activity was shown, and the enhancement of fibrinolysis was most pronounced during the first 30 minutes of exposure. Stimulation of fibrinolysis was maximal after exposure to the physiological concentration of 10(-9) M, while no further increase was seen using the pharmacological concentration. These results show that adrenaline has a stimulant effect on tissue fibrinolysis in vitro, and this effect may account for the direct stimulation of fibrinolysis by adrenaline in vivo.
在人体静脉活检标本中对肾上腺素对纤溶酶原激活物释放的影响进行了体外研究，其中根据纤维蛋白玻片技术测定纤溶活性。组织玻片覆盖有含10(-9)和10(-7)M肾上腺素的薄纤维蛋白膜，并暴露30至60分钟。在两种浓度下均显示出纤溶活性的高度显著增强（p小于0.001），并且在暴露的最初30分钟内纤溶增强最为明显。暴露于生理浓度10(-9)M后纤溶刺激最大，而使用药理浓度时未见进一步增加。这些结果表明，肾上腺素在体外对组织纤溶有刺激作用，并且这种作用可能解释了体内肾上腺素对纤溶的直接刺激。
