Lindemann H, Harbers E
Arzneimittelforschung. 1980;30(12):2075-80.
In vitro experiments were done for investigating the interactions of the three 3H-labelled alkylating drugs cyclophosphamide, ifosfamide and trofosfamide with DNA and DNA-constituents. Evidence is presented for a preferred reaction with orthophosphate groups, leading to phosphotriesters in the DNA. The results are discussed in view of the chemotherapeutic action of the drugs their mutagenic or carcinogenic effects.
进行了体外实验以研究三种3H标记的烷化剂药物环磷酰胺、异环磷酰胺和曲磷胺与DNA及DNA成分的相互作用。有证据表明它们优先与正磷酸基团反应，从而在DNA中形成磷酸三酯。鉴于这些药物的化疗作用、诱变或致癌作用对结果进行了讨论。
