Reuter H D, Schröter G
Arzneimittelforschung. 1980;30(12):2106-8.
Inzolen, a combination of the potassium, magnesium, copper, manganese and cobalt salts of aspartic acid, inhibits the second phase of ADP-induced aggregation probably by affecting the membrane-located adenylatecyclase/phosphodiesterase system. Correspondingly inzolen affects the activation of platelet factor 3 (PF3), which is also located in the platelet membrane. Thus spontaneous as well as kaolin-induced platelet factor availability is reduced by inzolen. The significant inhibition of factor 3 availability can be interpreted by a magnesium-mediated activation of phosphoryltransferases.
因唑啉是天冬氨酸的钾、镁、铜、锰和钴盐的混合物，可能通过影响位于细胞膜的腺苷酸环化酶/磷酸二酯酶系统来抑制二磷酸腺苷（ADP）诱导的聚集的第二阶段。相应地，因唑啉会影响同样位于血小板膜上的血小板因子3（PF3）的激活。因此，因唑啉会降低自发性以及高岭土诱导的血小板因子的可用性。因子3可用性的显著抑制可以通过镁介导的磷酸转移酶激活来解释。
