Vogt A, Neuhaus K L, Kreuzer H
Arzneimittelforschung. 1980;30(12):2162-4.
The hemodynamic effects of the new vasodilator drug isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylate (nisoldipine, Bay k 5552) were observed in 9 patients undergoing cardiac catheterization. The drug was administered i.v. in a dose of 1.5 microgram/kg body weight. Within 1 min after injection aortic pressure decreased by 11.5 +/- 6.4%, cardiac index increased by 23.1 +/- 13.5%, and heart rate accelerated by 18.3 +/- 10.1% of control value. Calculated total peripheral resistance was reduced by 28.2 +/- 10.1%. The whole low pressure system as well as the dp/dt max remained unaffected by the drug. The stroke volume index showed a slight and insignificant increase. Thus, Bay k 5552 represents a fast and power fully acting vasodilating substance with its actions being restricted mainly to the peripheral vasculature.
在9例接受心导管检查的患者中观察了新型血管扩张药异丁基甲基1,4 - 二氢 - 2,6 - 二甲基 - 4 -（2 - 硝基苯基）- 3,5 - 吡啶羧酸酯（尼索地平，Bay k 5552）的血流动力学效应。该药物以1.5微克/千克体重的剂量静脉注射。注射后1分钟内，主动脉压下降11.5±6.4%，心脏指数增加23.1±13.5%，心率加快至对照值的18.3±10.1%。计算得出的总外周阻力降低28.2±10.1%。整个低压系统以及dp/dt max未受该药物影响。每搏量指数有轻微且不显著的增加。因此，Bay k 5552是一种起效迅速且作用强大的血管扩张物质，其作用主要局限于外周血管系统。
