Asmussen B, Heinz N
Arzneimittelforschung. 1980;30(12):2168-72.
The drug release of four brands of digoxin tablets (A, B, C, D) with known bioavailability was examined using three liberation systems. The paddle method (1) could only ascertain a uniformly good release of all brands. A flow-cell (II) and a special method testing the supersaturation (III) indicated significant differences in drug release. Both II and III pointed to the brand having the best bioavailability. Beyond it no satisfactory correlation was found between the values of bioavailability and drug release.
使用三种释放系统对四种已知生物利用度的地高辛片剂（A、B、C、D）的药物释放情况进行了检测。桨法（I）仅能确定所有品牌片剂的释放情况均良好。流通池法（II）和一种检测过饱和度的特殊方法（III）表明药物释放在各品牌间存在显著差异。II和III均指出生物利用度最佳的品牌。除此之外，未发现生物利用度值与药物释放之间存在令人满意的相关性。
