胃癌肝转移患者的癌胚抗原、甲胎蛋白及癌胎盘碱性磷酸酶
Carcinoembryonic antigen, alpha-fetoprotein and carcinoplacental alkaline phosphatase in gastric carcinoma metastatic to the liver.
作者信息
Masuzawa M, Lee P K, Kamada T, Akeyama T, Abe H, Shimano T, Mori T, Morino H, Ishiguro S
出版信息
Cancer. 1977 Mar;39(3):1175-80. doi: 10.1002/1097-0142(197703)39:3<1175::aid-cncr2820390324>3.0.co;2-l.
Carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and carcinoplacental alkaline phosphatase (CPALP) were detected simultaneously in the sera and body fluids of two male patients with gastric carcinoma matestatic to the liver. At autopsy, widely disseminated gastric cancer of Borrmann III type with liver metastases was revealed in both bases. Histologically, they were moderately differentiated tubular and papillary adenocarcinomas with marked cellular atypia and necrosis. In Case 1, the properties of CPALP were identical to Nagao type CPALP, and in Case 2 the Variant type CPALP. Using immunofluorescence, CEA and CPALP were demonstrated in both primary and metastatic cells. However, only in Case 2 was AFP observed in some of the primary tumor cells.
在两名发生肝转移的男性胃癌患者的血清和体液中同时检测到癌胚抗原（CEA）、甲胎蛋白（AFP）和癌胎盘碱性磷酸酶（CPALP）。尸检发现，两名患者的肝脏均有广泛播散的Borrmann III型胃癌伴肝转移。组织学上，二者均为中度分化的管状和乳头状腺癌，伴有明显的细胞异型性和坏死。病例1中，CPALP的特性与长冈型CPALP相同；病例2中，CPALP为变异型。利用免疫荧光法，在原发肿瘤细胞和转移瘤细胞中均检测到CEA和CPALP。然而，仅在病例2的部分原发肿瘤细胞中观察到AFP。
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