Gábor M
Arzneimittelforschung. 1981;31(3):442-5.
The effect of three different oral doses of O-(beta-hydroxyethyl)-rutosides (HR, Venoruton) on the skin capillary resistance (CR) of Sprague-Dawley rats aged 8-10 weeks, 6 months or 1 year (and selected because of their low CR) was investigated. The CR was measured over a period of 24 h after a single administration of each dose. The results were compared with a further group aged 6 months who received HR intraperitoneally. The optimal dose was defined in all four groups receiving the drug systemically. In most cases a significant effect could be shown already after 2-4 h, persisting until at least 8 h and in some cases 24 h. Comparative data were also obtained with four different pure hydroxyethyl components (tetra-HR, tri-HR, di-HR and mono-7-HR) in identical experimental conditions. The most active appeared to be the mono-7-HR. Finally, the effect of a single topical application of a gel containing 2% HR was investigated. This produced a significant increase of CR after 1 h, which lasted around 4-5 h. The clinical implications of these results are discussed with special reference to senile, hypertensive and diabetic vascular disease.
研究了三种不同口服剂量的O-(β-羟乙基)-芦丁（HR，维脑路通）对8 - 10周龄、6个月龄或1岁的斯普拉格-道利大鼠（因其皮肤毛细血管阻力低而选取）皮肤毛细血管阻力（CR）的影响。在单次给予每种剂量后24小时内测量CR。将结果与另一组接受腹腔注射HR的6个月龄大鼠进行比较。在所有全身接受药物治疗的四组中确定了最佳剂量。在大多数情况下，给药后2 - 4小时即可显示出显著效果，持续至至少8小时，在某些情况下持续24小时。在相同实验条件下，还获得了四种不同的纯羟乙基成分（四-HR、三-HR、二-HR和单-7-HR）的比较数据。活性最强的似乎是单-7-HR。最后，研究了单次局部应用含2% HR的凝胶的效果。1小时后CR显著增加，持续约4 - 5小时。特别参照老年、高血压和糖尿病血管疾病讨论了这些结果的临床意义。
