Hellige G, Baller D, Ensink F B, Zipfel J, Wolpers H G, Bretschneider H J
Arzneimittelforschung. 1981;31(1a):155-6.
The effects of 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) on hemodynamics, myocardial oxygen consumption and cardiac pumping efficiency were tested on closed-chest dogs in cardiac catheterization technique. Doses in the range of 0.1 up to 4.0 mg/kg b. w. were injected i.v. A therapeutical dose is to be expected in the range of 1.0 mg/kg b. w., showing a distinct positive inotropic effect and reducing endsystolic volume without increase of heart rate and myocardial oxygen consumption.
采用心脏导管插入术技术，在开胸犬身上测试了2-[(2-甲氧基-4-甲亚磺酰基)苯基]-1H-咪唑并[4,5-b]吡啶（AR-L 115 BS）对血流动力学、心肌耗氧量和心脏泵血效率的影响。静脉注射剂量范围为0.1至4.0毫克/千克体重。预计治疗剂量在1.0毫克/千克体重范围内，显示出明显的正性肌力作用，可减少收缩末期容积，而不增加心率和心肌耗氧量。
