Schrader J
Arzneimittelforschung. 1981;31(1a):183-5.
The effects 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) and isoprenaline on some hemodynamic parameters of a stable isolated heart preparation from guinea pigs were studied. In the ventricular myocardium, AR-L 115 BS potentiated the inotropic effect of isoprenaline (8 x 10(-10) mol/l) in a dose dependent manner. The influence of AR-L 115 BS on heart rate in the presence and absence of isoprenaline was rather small. The possible role of catecholamines in modifying the effect of AR-L 115 BS is emphasized.
研究了2-[(2-甲氧基-4-甲基亚磺酰基)苯基]-1H-咪唑并[4,5-b]吡啶（AR-L 115 BS）和异丙肾上腺素对豚鼠稳定离体心脏标本某些血流动力学参数的影响。在心室心肌中，AR-L 115 BS以剂量依赖性方式增强了异丙肾上腺素（8×10⁻¹⁰ mol/l）的正性肌力作用。在有和没有异丙肾上腺素的情况下，AR-L 115 BS对心率的影响相当小。强调了儿茶酚胺在改变AR-L 115 BS作用方面的可能作用。
