[Close genetic relation between determinants coding for the HLA-D region, detected by the technique of mixed primary and secondary lymphocyte culture and by serology of B lymphocytes].

In this study we report that: 1. Li determinants serologically detectable or closely linked structures are more associated to secondary responses than HLA-D specificities defined by HTC testing; 2. Other determinants from loci, MHC linked, or cross reactivity between Li determinants must be postulated to explain discrepancies between secondary responses and B serology; 3. Li determinants have an effect on the intensity of the reaction in primary allogenic proliferation.