Williamson R A, Karp L E
Obstet Gynecol. 1981 Aug;58(2):247-50.
An infant born with preaxial polydactyly to a mother taking azathioprine throughout pregnancy is described. Experimental studies in animals reveal a teratogenic role for azathioprine and its main metabolite, 6-mercaptopurine. The skeletal system appears to be the primary tissue target for such action of these drugs. Although no direct cause-effect relationship can be established from the single case presented, the similarity of this anomaly to experimental azathioprine teratogenesis suggests the necessity for further surveillance.
本文描述了一名患有轴前多指畸形的婴儿，其母亲在整个孕期都服用硫唑嘌呤。动物实验研究表明硫唑嘌呤及其主要代谢产物6-巯基嘌呤具有致畸作用。骨骼系统似乎是这些药物这种作用的主要组织靶点。尽管从所呈现的单个病例中无法确立直接的因果关系，但这种异常与实验性硫唑嘌呤致畸作用的相似性表明有必要进行进一步监测。
