Katz U, Garcia-Romeu F, Masoni A, Isaia J
Pflugers Arch. 1981 Jun;390(3):299-300. doi: 10.1007/BF00658281.
Urea is accumulated in considerable amounts (greater than 100 mM) in the blood of the euryhaline toad Bufo viridis, under conditions of adaptation to high salinities. Salt adaptation increases active transport of urea (inward direction) in the skin, which was measured in vitro. The active transport of urea is insensitive to ADH, and was inhibited nearly 50% by 0.5 mM phloretin. This transport system is different from the facilitated diffusion of urea which has been studied extensively in the toad urinary bladder, and may offer a simple model system for the study of active urea transport.
在适应高盐度的条件下，广盐性蟾蜍绿蟾蜍血液中会积累大量尿素（超过100 mM）。盐适应会增加皮肤中尿素的主动转运（向内方向），这是在体外测量的。尿素的主动转运对抗利尿激素不敏感，0.5 mM根皮素可使其转运几乎抑制50%。该转运系统不同于在蟾蜍膀胱中已被广泛研究的尿素易化扩散，可能为研究尿素主动转运提供一个简单的模型系统。
