一种评估小鼠急性乙醇中毒的快速方法。

A rapid method of evaluate acute ethanol intoxication in mice.

作者信息

Blum K, Elston S F, Schwertner H, DeLallo L, Briggs A H

出版信息

Pharmacol Biochem Behav. 1981 Jun;14(6):835-8. doi: 10.1016/0091-3057(81)90370-1.

PMID:7196049

Abstract

A simple technique for the evaluation of ethanol intoxication based on the ability of mice to remain on a bar suspended above an electrified grid is reported. The characteristics that make this model useful to measure ethanol induced intoxication include: (a) low variability; (b) high sensitivity; (c) rapidity; (d) requires no previous training of animals to be tested; (e) objective scoring which can be quantified; and (f) dose-dependent correlation between brain and blood ethanol levels and bar holding response.

摘要

据报道，有一种基于小鼠在悬于带电网格上方的横杆上保持平衡的能力来评估乙醇中毒的简单技术。使该模型可用于测量乙醇诱导中毒的特征包括：（a）低变异性；（b）高敏感性；（c）快速性；（d）无需对受试动物进行预先训练；（e）可量化的客观评分；以及（f）脑乙醇水平和血乙醇水平与横杆支撑反应之间的剂量依赖性相关性。