Weinberg J B
Science. 1981 Aug 7;213(4508):655-7. doi: 10.1126/science.7196085.
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.
肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯可使人类白血病细胞系HL60的细胞分化为不分裂的巨噬细胞样细胞。这些分化细胞在体外对肿瘤细胞（包括亲本未处理的HL60细胞）具有细胞毒性。诱导这种向不分裂的抗肿瘤效应细胞的理想分化的试剂可能在白血病的实验治疗中有用。
