Angervall L, Kindblom L G, Nielsen J M, Stener B, Svendsen P
Cancer. 1978 Nov;42(5):2412-27. doi: 10.1002/1097-0142(197811)42:5<2412::aid-cncr2820420543>3.0.co;2-8.
A clinicopathologic study of 11 hemangiopericytomas is reported, and the results of clinical angiography in 4 patients and a correlated microangiographic-histologic study of 1 tumor are presented. Six of the tumors were collected and accepted as hemangiopericytomas in a review of 42 tumors registered as hemangiopericytoma in the Swedish Cancer Registry during the period 1958--1968. The other 5 tumors occurred in patients treated by us. The histologic examination and the follow-up information showed that it can be difficult to predict the prognosis on morphologic grounds, that borderline tumors exist and that a recurrence as well as a metastasis may dedifferentiate. The tumors studied by clinical angiography all proved to be highly vascular. Irregular vessels of varying caliber were filled with contrast medium and, in addition, a prominent diffuse opacification took place. Early filling of veins was not noted despite the high vascularity. The correlated microangiographic-histologic study suggests that the irregular vessels seen on clinical angiograms corresponded to wide, angulated, thin-walled vessels without muscle coat or elastic tissue, while the diffuse opacification was caused by a dense network of delicate, branching, slit-like capillary spaces.
本文报告了11例血管外皮细胞瘤的临床病理研究，并给出了4例患者的临床血管造影结果以及对1例肿瘤进行的相关微血管造影 - 组织学研究结果。在回顾瑞典癌症登记处1958 - 1968年间登记为血管外皮细胞瘤的42例肿瘤时，收集到6例并确认为血管外皮细胞瘤。另外5例肿瘤来自我们治疗的患者。组织学检查和随访信息表明，基于形态学依据难以预测预后，存在临界肿瘤，并且复发以及转移可能会发生去分化。经临床血管造影研究的肿瘤均显示为高血管性。不同管径的不规则血管充满造影剂，此外，还出现了明显的弥漫性造影剂充盈。尽管血管丰富，但未观察到静脉早期充盈。相关的微血管造影 - 组织学研究表明，临床血管造影中所见的不规则血管对应于宽的、有角度的、无肌层或弹性组织的薄壁血管，而弥漫性造影剂充盈是由密集的、纤细的、分支状的、裂隙样毛细血管间隙网络引起的。
