Hasumi K, Ehrmann R L
Cancer. 1978 Nov;42(5):2435-8. doi: 10.1002/1097-0142(197811)42:5<2435::aid-cncr2820420545>3.0.co;2-s.
In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occurrence in the uterine cervix and vagina, sites of mesonephric remnants. However, no clear evidence for mesonephric origin of clear cell carcinoma of the cervix and vagina has been ever provided. In contrast, there is substantial evidence that diethylstilbestrol-related clear cell carcinomas of the cervix and vagina are müllerian in origin. We report here a case of an exophytic clear cell carcinoma with an in situ component, involving the endocervical epithelium. The in situ lesion clearly indicates müllerian origin of the tumor, which occurred in the absence of prenatal exposure to diethylstilbestrol. This supports the general agreement that clear cell carcinomas of the cervix are müllerian in origin, whether diethylstilbestrol-related or not.
过去，所有女性生殖道透明细胞癌都被认为起源于中肾残余组织。最近，越来越多的证据表明它们起源于苗勒管上皮而非中肾上皮。支持其起源于中肾的一个主要原因是它们发生在子宫颈和阴道，即中肾残余组织所在的部位。然而，从未有过明确的证据证明子宫颈和阴道透明细胞癌起源于中肾。相反，有大量证据表明，与己烯雌酚相关的子宫颈和阴道透明细胞癌起源于苗勒管。我们在此报告一例有原位成分的外生性透明细胞癌病例，累及宫颈内膜上皮。原位病变清楚地表明肿瘤起源于苗勒管，该病例并未有产前接触己烯雌酚的情况。这支持了一个普遍的观点，即子宫颈透明细胞癌无论是否与己烯雌酚相关，均起源于苗勒管。
