Feuer L, Baráth P, Strauss I, Kékes E
Arzneimittelforschung. 1981;31(6):953-8.
7-Isopropoxy-isoflavone (Ipriflavone) treatment of rabbits for 8 days at daily oral doses of 30 mg/kg significantly decreases the oxygen consumption of their isolated hearts. In anoxia this effect is more pronounced. 10-day oral treatment of rabbits with 10 or 20 mg/kg/day of ipriflavone led to a significant decrease of the lactic acid content in the myocardium, especially, in the ischaemic region. A 6-day oral pre-treatment of rats with 30 mg/kg/day of ipriflavone significantly decreases the coronary ligation-induced damage of the mitochondria and myofibrils. Electron microscope autoradiography shows that ipriflavone significantly counteracts the coronary ligation induced calcium accumulation in the mitochondria. Ipriflavone seems to influence the mitochondrial energetics in a positive manner. It has an oxygen sparing effect.
7-异丙氧基异黄酮（依普黄酮）以每日30毫克/千克的口服剂量对兔子进行8天治疗，可显著降低其离体心脏的耗氧量。在缺氧状态下，这种作用更为明显。以每日10或20毫克/千克的依普黄酮对兔子进行10天口服治疗，可导致心肌中乳酸含量显著降低，尤其是在缺血区域。以每日30毫克/千克的依普黄酮对大鼠进行6天口服预处理，可显著降低冠状动脉结扎引起的线粒体和肌原纤维损伤。电子显微镜放射自显影显示，依普黄酮可显著对抗冠状动脉结扎引起的线粒体钙积累。依普黄酮似乎以积极的方式影响线粒体能量代谢。它具有氧节约效应。
