甘露糖苷贮积症中的血清和尿三糖。
Serum and urinary trisaccharides in mannosidosis.
作者信息
Lott I T, Daniel P F
出版信息
Neurology. 1981 Sep;31(9):1159-62.
A trisaccharide, Man2glcNAc, was the most abundant urinary oligosaccharide (161-558 mumol per liter) in a patient with mannosidosis. By means of a newly developed high-performance liquid chromatography (HPLC) procedure, we were able to measure low levels of serum trisaccharide (0.1--0.4 nmol per milliliter). This is the first report of the measurements of serum oligosaccharides in mannosidosis. Our observations on the disparate relationship between serum and urinary concentrations of this trisaccharide suggest that a facilitated renal clearance of oligosaccharides may be related to the nonprogressive aspect of this disorder.
一种三糖，甘露糖二糖（Man2glcNAc），是一名甘露糖苷贮积症患者尿液中最丰富的寡糖（每升161 - 558微摩尔）。通过一种新开发的高效液相色谱（HPLC）方法，我们能够测量到血清中低水平的三糖（每毫升0.1 - 0.4纳摩尔）。这是关于甘露糖苷贮积症患者血清寡糖测量的首次报告。我们对这种三糖血清和尿液浓度之间不同关系的观察表明，寡糖的肾清除率增加可能与该疾病的非进行性方面有关。
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