Brindley P J, Dobson C
Parasitology. 1981 Aug;83(Pt 1):51-65. doi: 10.1017/s0031182000050034.
Quackenbush strain and wild Mus musculus were assayed for their liability to primary infection with 100 L3 Nematospiroides dubius using an experimentally derived selection index. Refractory and liable colonies of mice were established over 5 generations. Liability to N. dubius infection was found likely to be controlled by several genes; the heritability (h2) of this trait was estimated at 0.45. Positive linear correlation was found between the number of parasite eggs voided and the number of adult N. dubius recovered, negative correlation between the pre-patent period of infection in days and the number of parasite eggs voided and positive correlation in 2 of 5 generations between live mouse body weight and the number of adult N. dubius recovered. Further, positive correlation was found between the liability of female mice to N. dubius and their progeny litter size number. The genetic mechanisms controlling the liability trait and the possible evolutionary significance of these results are discussed.
使用实验得出的选择指数，对夸肯布什品系小鼠和野生小家鼠进行检测，以评估它们对100条杜氏嗜气线虫第三期幼虫初次感染的易感性。经过5代培育，建立了对该寄生虫感染具有抗性和易感性的小鼠群体。发现对杜氏嗜气线虫感染的易感性可能受多个基因控制；该性状的遗传力（h2）估计为0.45。排出的寄生虫卵数量与回收的杜氏嗜气线虫成虫数量之间呈正线性相关，感染的潜伏期天数与排出的寄生虫卵数量之间呈负相关，在5代中的2代中，活小鼠体重与回收的杜氏嗜气线虫成虫数量之间呈正相关。此外，还发现雌性小鼠对杜氏嗜气线虫的易感性与其后代窝仔数之间呈正相关。本文讨论了控制易感性性状的遗传机制以及这些结果可能的进化意义。
