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[联合使用作用相似药物时增效或抑制作用的定量估计。剂量反应曲线法相对于等效线法的优势（作者译）]

[Quantitative estimation of potentiating or inhibitory effects of similarly acting drugs in combination. Advantages of a dose-response curve method over the isoboles-method (author's transl)].

作者信息

Pöch G

出版信息

Arzneimittelforschung. 1981;31(7):1135-40.

PMID:7196763
Abstract

Experimental effects of two synergistically acting drugs in combination can be compared with theoretical additive effects by means of various methods. In this paper a new method has been extended and analyzed for its advantages over the isoboles method. The main advantages of the new method are the simplicity of the experimental technique of combination-experiments, the evaluation in terms of dose-response curves and the adequate quantitative determination of non-additive combination effects. The method allows the evaluation of the mode of action of effects brought about in combination, e.g., in functional and sequential potentiation.

摘要

两种具有协同作用的药物联合使用时的实验效果，可以通过各种方法与理论相加效果进行比较。本文扩展并分析了一种新方法相对于等效线法的优势。新方法的主要优点包括联合实验的实验技术简单、根据剂量反应曲线进行评估以及对非相加联合效应进行充分的定量测定。该方法能够评估联合产生的效应的作用模式，例如功能增强和序贯增强。

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