Tallarida Ronald J
Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140, USA.
J Pharmacol Exp Ther. 2006 Oct;319(1):1-7. doi: 10.1124/jpet.106.104117. Epub 2006 May 2.
Drugs given in combination may produce effects that are greater than or less than the effect predicted from their individual potencies. The historical basis for predicting the effect of a combination is based on the concept of dose equivalence; i.e., an equally effective dose (a) of one will add to the dose (b) of the other in the combination situation. For drugs with a constant relative potency, this leads to linear additive isoboles (a-b curves of constant effect), whereas a varying potency ratio produces nonlinear additive isoboles. Determination of the additive isobole is a necessary procedure for assessing both synergistic and antagonistic interactions of the combination. This review discusses both variable and constant relative potency situations and provides the mathematical formulas needed to distinguish these cases.
联合使用的药物可能产生的效果大于或小于根据其各自效力预测的效果。预测联合用药效果的历史依据基于剂量等效性的概念；也就是说，在联合用药的情况下，一种药物的等效有效剂量（a）将与另一种药物的剂量（b）相加。对于相对效力恒定的药物，这会导致线性相加等效应线（恒定效应的a-b曲线），而效力比变化则会产生非线性相加等效应线。确定相加等效应线是评估联合用药协同和拮抗相互作用的必要步骤。本综述讨论了相对效力可变和恒定的情况，并提供了区分这些情况所需的数学公式。
