Sims P J, Boswell E B
Blood. 1981 Oct;58(4):682-4.
The level of platelet-associated IgG (PAIgG) were measured during the successful treatment of a patient with thrombotic thrombocytopenic purpura. Prior to therapy. PAIgG was found to be markedly elevated to 195 fg/cell (normal range 0--3.5 fg/cell). The institution of combined therapy with intensive plasma exchange transfusions, high-dose steroids, and antiplatelet drugs resulted in a complete recovery and a decline in PAIgG to the normal range. The possible role of platelet antibody in the pathogenesis of this disorder is discussed.
在成功治疗一名血栓性血小板减少性紫癜患者的过程中，对血小板相关IgG（PAIgG）水平进行了检测。治疗前，发现PAIgG显著升高至195 fg/细胞（正常范围为0 - 3.5 fg/细胞）。采用强化血浆置换输血、大剂量类固醇和抗血小板药物联合治疗后，患者完全康复，PAIgG降至正常范围。本文讨论了血小板抗体在该疾病发病机制中的可能作用。
