Bodensteiner D, Rosenfeld C
Department of Medicine, University of Kansas Medical Center, Kansas City 66103.
South Med J. 1988 Jan;81(1):81-3. doi: 10.1097/00007611-198801000-00017.
The level of platelet-surface-bound IgM (PSIgM) was measured during the course of therapy in two patients with thrombotic thrombocytopenic purpura (TTP). Before therapy, both had significantly elevated PSIgM. In both cases the PSIgM dropped after the institution of treatment with plasmapheresis, steroids, and dipyridamole, correlating with a complete response to therapy in one patient and a partial response in the second. This is further evidence that in some cases of TTP, an immune mechanism is present.
在两名血栓性血小板减少性紫癜（TTP）患者的治疗过程中，对血小板表面结合免疫球蛋白M（PSIgM）水平进行了检测。治疗前，两人的PSIgM均显著升高。在这两个病例中，采用血浆置换、类固醇和双嘧达莫治疗后，PSIgM均下降，其中一名患者对治疗完全缓解，另一名患者部分缓解。这进一步证明，在某些TTP病例中，存在免疫机制。
