Jirtle R L, Clifton K H
Cell Tissue Kinet. 1978 Nov;11(6):581-96. doi: 10.1111/j.1365-2184.1978.tb00832.x.
Experiments were designed to clarify the causes of anaemia in hosts bearing tumours in either unirradiated or preirradiated tissue. Isotopic methods are described which enable the estimation of erythrocyte destruction and production rates, and the potential red cell life spans in tumour-bearing animals. In this experimental system, anaemia (a) is in large part due to accelerated random erythrocyte loss, (b) is exacerbated as tumours grow by a progressive reduction in the potential erythrocyte life span due to intrinsic erythrocyte defects, (c) is accompanied by an increase in erythrocyte production of six- to ten-fold and (d) is postponed in onset and decreased in magnitude by preirradiation of the tumour transplant site.
实验旨在阐明在未受照射或预先受照射组织中携带肿瘤的宿主发生贫血的原因。文中描述了同位素方法，这些方法能够估计红细胞破坏率和生成率，以及荷瘤动物潜在的红细胞寿命。在这个实验系统中，贫血：(a) 在很大程度上是由于随机红细胞丢失加速；(b) 随着肿瘤生长，由于内在红细胞缺陷导致潜在红细胞寿命逐渐缩短而加剧；(c) 伴有红细胞生成增加6至10倍；(d) 通过对肿瘤移植部位进行预先照射，贫血的发生延迟且程度减轻。
