Klingensmith W C, Fritzberg A R, Spitzer V M, Kuni C C, Shanahan W S
Radiology. 1981 Sep;140(3):791-5. doi: 10.1148/radiology.140.3.7197041.
Thirty-one patients with a wide range of hepatobiliary function and clinical diagnoses were studied with both diisopropyl-IDA Tc 99m and diethyl-IDA Tc 99m. Images were similar except for an increased liver-to-kidney ratio with diisopropyl-IDA Tc 99m (p less than 0.01) and a tendency toward an increased liver-to-background ratio at five minutes with diisopropyl-IDA Tc 99m (p greater than 0.05). Quantification of the relative hepatocyte extraction efficiency indicated a 16% higher extraction efficiency for diisopropyl-IDA Tc 99m (p greater than 0.05). Cumulative three-hour urine collections following injection demonstrated no significant difference in renal excretion in patients with normal total serum bilirubin levels. Both radiopharmaceuticals demonstrated increasing renal excretion with increasing total serum bilirubin levels; however, renal excretion of diisopropyl-IDA Tc 99m increased more slowly than excretion of diethyl-IDA Tc 99m (p less than 0.01). We conclude that, while the overall differences between these two radiopharmaceuticals are small, diisopropyl-IDA Tc 99m is superior because of a lower renal excretion rate in patients with decreased hepatocyte function.
对31例具有广泛肝胆功能和临床诊断的患者，使用二异丙基-IDA Tc 99m和二乙基-IDA Tc 99m进行了研究。除了二异丙基-IDA Tc 99m的肝-肾比值增加（p小于0.01）以及二异丙基-IDA Tc 99m在5分钟时肝-本底比值有增加趋势（p大于0.05）外，图像相似。相对肝细胞摄取效率的定量分析表明，二异丙基-IDA Tc 99m的摄取效率高16%（p大于0.05）。注射后3小时的累积尿液收集显示，总血清胆红素水平正常的患者肾排泄无显著差异。两种放射性药物均显示随着总血清胆红素水平的升高肾排泄增加；然而，二异丙基-IDA Tc 99m的肾排泄增加比二乙基-IDA Tc 99m慢（p小于0.01）。我们得出结论，虽然这两种放射性药物之间的总体差异较小，但由于肝细胞功能降低的患者肾排泄率较低，二异丙基-IDA Tc 99m更具优势。
