一项比较锝-99m标记的二乙基和二异丙基亚氨基二乙酸动力学的交叉研究。

A crossover study comparing the kinetics of Tc-99m-labeled diethyl- and diisopropyl-IDA.

作者信息

Hernandez M, Rosenthall L

出版信息

Clin Nucl Med. 1980 Aug;5(8):352-8. doi: 10.1097/00003072-198008000-00004.

DOI:10.1097/00003072-198008000-00004

PMID:7190477

Abstract

Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-diethyl-IDA (DE-IDA) were compared in each of 44 patients who had serum bilirubin levels ranging from normal to 50 mg/dl. Quantitative and qualitative analysis showed a significantly higher liver uptake relative to background for DISIDA. No significant differences between DISIDA and DE-IDA were found in the blood retention and rate of liver washout. Clinically, the diagnostic information received from both radiopharmaceuticals was essentially the same.

摘要

对44例血清胆红素水平从正常到50mg/dl的患者，分别比较了锝-99m-二异丙基-亚氨基二乙酸（DISIDA）和锝-99m-二乙基-亚氨基二乙酸（DE-IDA）。定量和定性分析表明，相对于本底，DISIDA的肝脏摄取显著更高。在血液滞留和肝脏洗脱率方面，未发现DISIDA和DE-IDA之间存在显著差异。临床上，从这两种放射性药物获得的诊断信息基本相同。