旷场实验：一种显示乙醇戒断症状的简单方法。
The open field: a simple method to show ethanol withdrawal symptoms.
作者信息
Capaz F R, Vanconcellos L E, De Moraes S, Neto J P
出版信息
Arch Int Pharmacodyn Ther. 1981 Jun;251(2):228-36.
The effects of withdrawal from chronic ethanol administration on locomotion and rearing frequencies of rats and mice were studied. Ethanol withdrawal induced a significant increase in animal's activity. In mice a positive correlation was found between locomotion plus rearing frequencies and audiogenic-induced seizures susceptibility 25 hr after ethanol removal. Results show that general activity evaluated through the open-field method might be used as a simple, non-drastic and reliable procedure to detect ethanol withdrawal symptoms in laboratory animals.
研究了长期给予乙醇后戒断对大鼠和小鼠运动及竖毛频率的影响。乙醇戒断导致动物活动显著增加。在小鼠中，去除乙醇25小时后，运动加竖毛频率与听源性惊厥易感性之间存在正相关。结果表明，通过旷场法评估的一般活动可能是一种简单、温和且可靠的方法，用于检测实验动物的乙醇戒断症状。
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