去除端脑可使向黑质注射GABA激动剂和拮抗剂所诱导的旋转得以保留。

Removal of the telencephalon spares turning induced by injection of GABA agonists and antagonists into the substantia nigra.

作者信息

Papadopoulos G, Huston J P

出版信息

Behav Brain Res. 1980 Feb;1(1):25-38. doi: 10.1016/0166-4328(80)90044-3.

PMID:7197156

Abstract

Unilateral injections into the substantia nigra of GABA agonists or the GABA-related agents muscimol (5-50 ng), baclofen (10-50 ng) or B-aminobutyric acid (25-50 ug) induced intensive turning in the direction contralateral to the injected hemisphere. Intranigral injection of the GABA antagonist picrotoxin (100-500 ng) led to ipsiversive turning. Surgical removal of the whole telencephalon (including the neocortex, hippocampus, striatum, septal nuclei and amygdalae) influenced neither direction nor magnitude of the turning responses induced by these various drugs. A GABAergic system in the substantia nigra can, therefore, cause turning independent of telencephalic structures.

摘要

向黑质单侧注射γ-氨基丁酸（GABA）激动剂或与GABA相关的药物蝇蕈醇（5 - 50纳克）、巴氯芬（10 - 50纳克）或β-氨基丁酸（25 - 50微克）会导致动物向注射半球对侧剧烈旋转。向黑质内注射GABA拮抗剂印防己毒素（100 - 500纳克）会导致动物向同侧旋转。手术切除整个端脑（包括新皮层、海马体、纹状体、隔核和杏仁核）对这些不同药物诱导的旋转反应的方向和幅度均无影响。因此，黑质中的GABA能系统可独立于端脑结构引起旋转。