Allen E R, Murphy B J
Cell Tissue Res. 1978 Nov 9;194(1):125-30. doi: 10.1007/BF00209238.
Dilations of the sarcotubular system and misaligned myofilaments have been reported as early indicators of muscular dystrophy in skeletal muscle. Since the developing tubular component is believed instrumental in initial myofilament alignment during myogenesis, tubular development is evaluated using normal and dystrophic chick embryo skeletal muscle and cultures of normal and dystrophic embryonic pectoral muscle incubated in the presence of horse spleen ferritin. Comparisons of the findings show that periodic tubules are absent from dystrophic somitic muscle and that invaginating tubules from the sarcolemma are found in fewer, randomly located areas of dystrophic pectoral muscle cells. The results indicate that the tubular component is not involved in the bizarre vesiculations seen in mature dystrophic muscle, however, the malalignment of dystrophic myofilaments is probably the result of the poorer development of the T system in this muscle.
肌管系统扩张和肌丝排列紊乱已被报道为骨骼肌营养不良的早期指标。由于发育中的管状成分被认为在肌生成过程中对初始肌丝排列起重要作用，因此使用正常和营养不良的鸡胚骨骼肌以及在马脾铁蛋白存在下培养的正常和营养不良胚胎胸肌来评估管状结构的发育。对研究结果的比较表明，营养不良的体节肌中没有周期性小管，并且在营养不良的胸肌细胞中，来自肌膜的内陷小管出现在较少的、随机分布的区域。结果表明，管状成分与成熟营养不良肌肉中出现的奇异小泡形成无关，然而，营养不良肌丝的排列紊乱可能是该肌肉中T系统发育较差的结果。
