Jacob J J, Ramabadran K, Campos-Medeiros M
J Clin Pharmacol. 1981 Aug-Sep;21(S1):327S-333S. doi: 10.1002/j.1552-4604.1981.tb02611.x.
Using the hot plate test, the potency and mechanism of the analgesic activity of levonantradol was studied in mice. Levonantradol is 10 to 30 times more potent than morphine; the antinociception can be only partially blocked by naloxone. Similar limited antagonism by cholinergics indicates possible opiodergic mechanism. The role of serotoninergic pathways is unclear; antinociception is partially blocked by 5,7-dihydroxytryptamine, unaffected by p-chlorophenylalanine, and potentiated by cyproheptadine. Levonantradol blocks naloxone-induced signs of abstinence in morphine-dependent mice, being 3000 times more potent than morphine and 300 times more potent than delta 9-tetrahydrocannabinol (THC).
利用热板试验，在小鼠中研究了左那曲朵镇痛活性的效能和机制。左那曲朵的效能是吗啡的10至30倍；其抗伤害感受作用仅能被纳洛酮部分阻断。胆碱能药物类似的有限拮抗作用表明可能存在阿片样物质机制。血清素能途径的作用尚不清楚；抗伤害感受作用可被5,7 - 二羟基色胺部分阻断，不受对氯苯丙氨酸影响，而被赛庚啶增强。左那曲朵可阻断吗啡依赖小鼠中纳洛酮诱导的戒断症状，其效能是吗啡的3000倍，是δ9 - 四氢大麻酚（THC）的300倍。
