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给予纳曲多、左啡诺或N-甲基左啡诺后松鼠猴的电击滴定法

Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-methyl levonantradol.

作者信息

Dykstra L A

出版信息

Psychopharmacology (Berl). 1983;79(4):322-4. doi: 10.1007/BF00433410.

DOI:10.1007/BF00433410
PMID:6407046
Abstract

The effects of some cannabinoid-related analgesics were examined in squirrel monkeys responding under a schedule of shock titration. Nantradol (0.1-0.3 mg/kg), levonantradol (0.03-0.1 mg/kg), or N-methyl levonantradol (0.01-0.03 mg/kg) increased the level at which shock was maintained, but did not change rates of responding. Nantradol effects were not blocked by naloxone (0.3-3.0 mg/kg), but they were attenuated following daily administration of nantradol.

摘要

在松鼠猴按照电击滴定程序做出反应的情况下，对一些与大麻素相关的镇痛药的效果进行了研究。纳曲多（0.1 - 0.3毫克/千克）、左纳曲多（0.03 - 0.1毫克/千克）或N - 甲基左纳曲多（0.01 - 0.03毫克/千克）提高了维持电击的水平，但没有改变反应速率。纳曲多的效果不受纳洛酮（0.3 - 3.0毫克/千克）的阻断，但在每日给予纳曲多后其效果会减弱。

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Psychopharmacology (Berl). 1983;79(4):322-4. doi: 10.1007/BF00433410.
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本文引用的文献

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Effects of morphine, levonantradol, and N-methyllevonantradol on shock intensity discrimination.吗啡、左那曲朵和N-甲基左那曲朵对休克强度辨别的影响。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):341S-347S. doi: 10.1002/j.1552-4604.1981.tb02613.x.
2
Nantradol hydrochloride: pharmacokinetics and behavioral effects after acute and chronic treatment.盐酸南曲朵：急性和慢性治疗后的药代动力学及行为效应
J Pharmacol Exp Ther. 1981 Nov;219(2):363-9.
3
Effectiveness of nantradol in blocking narcotic withdrawal signs through nonnarcotic mechanisms.
纳曲酮通过非麻醉机制阻断麻醉品戒断症状的有效性。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):361S-366S. doi: 10.1002/j.1552-4604.1981.tb02615.x.
4
A pharmacological analysis of levonantradol antinociception in mice.左那曲朵对小鼠的镇痛作用的药理学分析。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):327S-333S. doi: 10.1002/j.1552-4604.1981.tb02611.x.
5
Evaluation of intramuscular levonantradol and placebo in acute postoperative pain.肌肉注射左纳曲朵与安慰剂用于术后急性疼痛的评估。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):320S-326S. doi: 10.1002/j.1552-4604.1981.tb02610.x.
6
The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat.鞘内注射左南曲朵和去乙酰左南曲朵对大鼠的镇痛作用。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):334S-340S. doi: 10.1002/j.1552-4604.1981.tb02612.x.
7
Behavioral effects of levonantradol and nantradol in the rhesus monkey.左纳曲朵和纳曲朵对恒河猴的行为影响。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):348S-360S. doi: 10.1002/j.1552-4604.1981.tb02614.x.
8
A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog.四氢大麻酚、纳曲酮、纳必隆与吗啡在慢性脊髓犬体内的比较。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):311S-319S. doi: 10.1002/j.1552-4604.1981.tb02609.x.
9
Stereospecific and potent analgetic activity for nantradol--a structurally novel, cannabinoid-related analgetic.纳曲多（nantradol）具有立体特异性和强效镇痛活性——一种结构新颖、与大麻素相关的镇痛药。
NIDA Res Monogr. 1979;27:84-92.
10
Effects of morphine, pentazocine and cyclazocine alone and in combination with naloxone on electric shock titration in the squirrel monkey.吗啡、喷他佐辛和环佐辛单独及与纳洛酮联合应用对松鼠猴电击滴定的影响。
J Pharmacol Exp Ther. 1979 Dec;211(3):722-32.