Heinz N
Arzneimittelforschung. 1981;31(9):1469-71.
Using appropriate transformations the relationship between the frequency of digoxin intoxication and the corresponding digoxin plasma levels can be shown to be linear. Therefore the relative frequencies have to be transformed into probits and the digoxin plasma levels have to be replaced by their logarithms. With intoxication frequencies from published data the IC50, i.e., the plasma level leading to an intoxication in 50% of cases, is 2.9 ng/ml. At 1.0 ng/ml the intoxication frequency is estimated below 1%, at 4.0 ng/ml the estimated frequency is just below 80%. In the intoxication diagnosis of a single patient the plasma level is of only poor significance.
通过适当的变换可以表明，地高辛中毒频率与相应的地高辛血浆水平之间的关系呈线性。因此，相对频率必须转换为概率单位，地高辛血浆水平必须用其对数代替。根据已发表数据中的中毒频率，半数致死浓度（IC50），即导致50%病例中毒的血浆水平为2.9纳克/毫升。在血浆水平为1.0纳克/毫升时，中毒频率估计低于1%；在4.0纳克/毫升时，估计频率略低于80%。在单个患者的中毒诊断中，血浆水平的意义不大。
