Boscherini B, Iannaccone G, La Cauza C, Mancuso G, Girotti F, Finocchi G, Pasquino A M
Eur J Pediatr. 1981 Oct;137(2):237-42. doi: 10.1007/BF00441325.
Two cases of severe intrauterine growth retardation, a boy and a girl studied for 7 and 10 years respectively, are reported. Both patients showed peculiar cranio-facial abnormalities as observed in the so-called Seckel's syndrome, an appearance of premature aging, peripheral GH resistance which was probably due to deficiency in Somatomedin A production, sella areas and volumes consistently at the upper limits of normal when related to the patients' height, and dysharmonic skeletal maturation ivory cone-shaped epiphyses of the tubular bones of the hands.
报告了两例严重宫内生长迟缓病例，分别是一名男孩和一名女孩，研究时间分别为7年和10年。两名患者均表现出在所谓的塞克尔综合征中观察到的特殊颅面异常、早衰外观、外周生长激素抵抗（这可能是由于生长调节素A产生不足所致）、与患者身高相关时蝶鞍面积和体积始终处于正常上限，以及手部管状骨的骨骺呈不协调的骨骼成熟象牙锥形。
