Hernandez R, Poznanski A K, Kelch R P, Kuhns L R
AJR Am J Roentgenol. 1977 Sep;129(3):487-92. doi: 10.2214/ajr.129.3.487.
Hand radiographs in 10 male patients (eight white, two black) with isolated growth hormone deficiency were studied before and after treatment. The length of the second metacarpal was the most significantly depressed measurement when considered by chronologic age and responded most to treatment with human growth hormone. All patients had osteoporosis even when evaluated by height age. The bone mass improved with treatment by subperiosteal new bone apposition. Skeletal maturation was retarded with the carpals showing more severe retardation than the tubular bones and responding more dramatically to treatment. The depression in height age and carpal age was very similar, indicating that the carpal age may have the greatest correlation with height. The greater sensitivity of the carpal age deficiency of growth hormone and its greater response to treatment suggest that the carpal age and the phalangeal-metacarpal age should be considered independently during evaluation of skeletal maturation.
对10例单纯生长激素缺乏的男性患者（8例白人，2例黑人）治疗前后的手部X光片进行了研究。按实际年龄来看，第二掌骨长度是受影响最显著的测量指标，对人生长激素治疗反应也最为明显。即便按身高年龄评估，所有患者均存在骨质疏松。经骨膜下新骨附着治疗后，骨量有所改善。骨骼成熟延迟，腕骨比管状骨表现出更严重的延迟，且对治疗反应更显著。身高年龄和腕骨年龄的降低非常相似，表明腕骨年龄可能与身高的相关性最大。生长激素缺乏时腕骨年龄更敏感，对治疗反应也更大，这表明在评估骨骼成熟时，应独立考虑腕骨年龄和掌指骨年龄。
