Hata T, Ohkawa K, Uchida K, Kamitani N
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Nov;33(11):1917-24.
To elucidate the mechanism of trophoblastic penetration into maternal vessels and the function of the trophoblast replacing the endothelium, feto-maternal junctional zone (FMJZ) removed from human uteri in early gestational stages of 4 to 11 weeks were morphologically investigated. The trophoblast cells which can approach to or penetrate the maternal vessels and can replace the endothelial cell were only syncytiotrophoblast cells. Since microfilaments aggregated in bundle in cytoplasm of the syncytiotrophoblast cells which are approaching to the maternal vessel inserted into dense bodies or dense patches, it is considered that the microfilaments are composed of thin filaments mainly like in smooth muscle cell. Degranulation of rER and lysosomal structure or aggregation of microfilaments are occurred in endothelial cells penetrated or closely contacted by field horsetail-like cytoplasmic processes of syncytiotrophoblast cell, respectively. It is possible that the syncytiotrophoblast cell and maternal endothelial cell have similar origin, since both cell can be in close contact with tight junction and simple apposition like intrinsic endothelial junction.
为了阐明滋养层细胞侵入母体血管的机制以及滋养层细胞取代内皮细胞的功能，对从4至11周早期妊娠阶段的人子宫中取出的母胎交界区（FMJZ）进行了形态学研究。能够接近或侵入母体血管并能取代内皮细胞的滋养层细胞仅为合体滋养层细胞。由于在接近插入致密体或致密斑的母体血管的合体滋养层细胞的细胞质中微丝成束聚集，因此认为微丝主要由类似于平滑肌细胞中的细肌丝组成。分别在被合体滋养层细胞的田间马尾状细胞质突起穿透或紧密接触的内皮细胞中发生粗面内质网脱颗粒和溶酶体结构变化或微丝聚集。合体滋养层细胞和母体内皮细胞可能具有相似的起源，因为这两种细胞可以通过紧密连接和简单并列紧密接触，就像内在的内皮连接一样。
