Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Pediatr. 2012 Apr;160(4):573-577.e1. doi: 10.1016/j.jpeds.2011.09.016. Epub 2011 Nov 4.
To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates.
This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions.
There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66).
Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.
评估新生儿脐血镁浓度与产房复苏水平之间的关系。
这是一项对胎儿神经保护试验的二次分析，该试验纳入了妊娠 24 至 31 周即将分娩的高危妇女，并随机分配她们接受静脉注射硫酸镁或安慰剂治疗。该队列包括 1507 名婴儿，其脐带血 Mg 浓度和产房复苏数据可用。采用多变量逻辑回归，使用以下层次结构来估计脐血 Mg 浓度与产房复苏的最高水平之间的关系：无、仅吸氧、带氧面罩通气、插管和胸外按压。
脐血 Mg 与产房复苏之间无相关性（OR，每增加 1.0 mEq/L，为 0.92；95%CI，0.83-1.03）。母亲全身麻醉与新生儿复苏增加相关（OR，2.51；95%CI，1.72-3.68）。出生时每增加一周的胎龄与新生儿复苏减少相关（OR，0.63；95%CI，0.60-0.66）。
暴露于硫酸镁进行胎儿神经保护的婴儿的脐血镁浓度与产房复苏水平不相关。
