Horowitz G P, Allan A M
Pharmacol Biochem Behav. 1982 Jan;16(1):35-9. doi: 10.1016/0091-3057(82)90009-0.
Mice which have been selectively bred for differences in sensitivity to acute doses of alcohol have also been shown to differ in severity of seizures upon withdrawal from chronic alcohol administration. We investigated the responsiveness of these mice to withdrawal from chronic morphine treatment. Mice were made dependent on morphine via pellet implantation, and withdrawal was precipitated with naloxone challenge. Mice which are less sensitive to the hypnotic effects of ethanol (short sleep: SS) displayed more jumping and wet dog shakes during withdrawal than did the more sensitive long sleep (LS) mice. In addition, the amount of jumping was dependent on the dose of naloxone in both lines. Differences between lines in naloxone precipitated withdrawal may reflect differences in alterations in extrapyramidal dopaminergic activity, but other substrates for the observed differences cannot be discounted. Finally, the observed difference between SS and LS mice in severity of morphine withdrawal parallels the previously reported difference between these lines in seizure severity during withdrawal from alcohol.
经过选择性培育以使其对急性酒精剂量的敏感性存在差异的小鼠，在从长期酒精给药中戒断时，癫痫发作的严重程度也显示出不同。我们研究了这些小鼠对从长期吗啡治疗中戒断的反应性。通过植入药丸使小鼠对吗啡产生依赖性，并用纳洛酮激发来促使戒断。对乙醇催眠作用不太敏感的小鼠（短睡眠：SS）在戒断期间比更敏感的长睡眠（LS）小鼠表现出更多的跳跃和湿狗样抖动。此外，两个品系的跳跃量均取决于纳洛酮的剂量。纳洛酮引发的戒断反应在品系间的差异可能反映了锥体外系多巴胺能活动改变的差异，但观察到的差异的其他底物也不能排除。最后，在吗啡戒断严重程度方面，SS小鼠和LS小鼠之间观察到的差异与之前报道的这两个品系在酒精戒断期间癫痫发作严重程度的差异相似。
