Kest B, McLemore G L, Sadowski B, Mogil J S, Belknap J K, Inturrisi C E
Department of Psychology, The College of Staten Island/CUNY, NY 10314, USA.
Neurosci Lett. 1998 Nov 6;256(2):120-2. doi: 10.1016/s0304-3940(98)00772-1.
Acute morphine dependence was compared in mice selectively-bred for high (HA) and low (LA) swim stress-induced analgesia and high (HAR) and low (LAR) levorphanol analgesia by counting the number of naloxone-precipitated jumps. Whereas LAR mice displayed greater acute morphine dependence than HAR mice, HA and LA mice did not differ. No genotypic differences were observed in non-dependent mice, discounting possible differences in basal naloxone sensitivity and/or opioid peptide levels. Thus, the two selection projects, while both producing lines exhibiting highly divergent sensitivity to morphine analgesia, have not had analogous effects on all opioid measures, supporting the notion of independent genetic mediation of opioid analgesia and dependence. Further, these data suggest that analgesic sensitivity may not predict sensitivity to morphine dependence.
通过计算纳洛酮诱发的跳跃次数，对选择性培育的高（HA）、低（LA）游泳应激诱导镇痛以及高（HAR）、低（LAR）左啡诺镇痛的小鼠的急性吗啡依赖性进行了比较。虽然LAR小鼠比HAR小鼠表现出更强的急性吗啡依赖性，但HA和LA小鼠没有差异。在非依赖性小鼠中未观察到基因型差异，排除了基础纳洛酮敏感性和/或阿片肽水平可能存在的差异。因此，这两个选育项目虽然都培育出了对吗啡镇痛敏感性差异很大的品系，但对所有阿片类指标并没有类似的影响，这支持了阿片类镇痛和依赖性由独立基因介导的观点。此外，这些数据表明镇痛敏感性可能无法预测对吗啡依赖性的敏感性。
