一种人类补体前体蛋白——C3前体在肝癌衍生细胞系中的生物合成与加工
Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.
作者信息
Morris K M, Goldberger G, Colten H R, Aden D P, Knowles B B
出版信息
Science. 1982 Jan 22;215(4531):399-400. doi: 10.1126/science.7199205.
PMID:7199205
Abstract
A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.
摘要
一种180,000道尔顿的单链分子（人C3前体）是人类补体第三成分（C3）的前体，C3是一种通过二硫键连接的双链蛋白质。C3前体通过有限的蛋白水解作用转化为C3。利用Hep G2（一种源自人肝细胞癌的细胞系，可合成至少17种血浆蛋白）确定了C3前体与C3之间的关系。
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