Hartert H
Arzneimittelforschung. 1981;31(11a):2035-9.
Among the earliest products of a potentially succeeding disseminated intravascular coagulation (DIC) are the soluble fibrin monomer complexes representing a state of hypercoagulability. They are passing microcirculation as long as there are no precipitation activities, which may involve only one single organ. A typical example is the endotoxin shock followed by fibrination of the kidneys. The clogging of microcirculation by fibrination specifically released in this organ or another may be prevented in case of a well-timed diagnosis, but scarcely can be removed therapeutically (possibly therapeutical fibrinolysis). The effects of localising fibrination yet independent of clotting mechanism may be tackled by treating the causal disease. Hypercoagulability always preceding DIC can be controlled mainly by heparin. Its well-timed application depends on diagnostics which are able to define the momentary situation in the mostly progredient process, comprising a mortality of about 50%. Finally, as a possible method to assess the clinical situation the resonance thrombography, a successor of thrombelastography, is put forward.
潜在的后继弥散性血管内凝血（DIC）最早的产物之一是可溶性纤维蛋白单体复合物，代表高凝状态。只要没有沉淀活动，它们就会通过微循环，沉淀活动可能仅涉及一个单一器官。一个典型的例子是内毒素休克后肾脏发生纤维蛋白沉积。如果诊断及时，可能会防止在该器官或其他器官中特异性释放的纤维蛋白沉积导致微循环阻塞，但几乎无法通过治疗消除（可能是治疗性纤维蛋白溶解）。针对病因疾病进行治疗可以解决与凝血机制无关的局部纤维蛋白沉积的影响。总是先于DIC出现的高凝状态主要可以通过肝素进行控制。其及时应用取决于能够确定这个大多呈进行性发展且死亡率约为50%的过程中当前情况的诊断方法。最后，作为评估临床情况的一种可能方法，提出了共振血栓图，它是血栓弹力图的后继技术。
