Walker B L, Hahn P
Can J Biochem. 1981 Nov-Dec;59(11-12):889-92. doi: 10.1139/o81-124.
Liver microsomal 3-hydroxy-3-methylglutaryl-CoA (HMGCoA) reductase activity increases after parturition in the female rat. The elevated activity observed within 24- to 36-h postpartum was sustained throughout lactation but declined to control levels by day 30, the natural weaning age of the pups. Premature weaning, induced by removal of the offspring, returned HMGCoA reductase activity to normal within 2-4 days. The elevation in HMGCoA reductase was not due to elimination or inversion of the natural diurnal rhythm of this enzyme, which was similar in phase, but not in amplitude, in lactating and control animals. Elevated feed intake in the lactating animal may have contributed to the increase in HMGCoA reductase since pair feeding with a nonpregnant, nonlactating control rat abolished the elevation in enzyme activity observed during lactation. Elevated food intake did not induce the elevation in HMGCoA reductase in lactating rats, however, since the major change in food intake occurred after the initial increase in enzyme activity.
雌性大鼠产后肝脏微粒体3-羟基-3-甲基戊二酰辅酶A（HMGCoA）还原酶活性增加。产后24至36小时内观察到的活性升高在整个哺乳期持续存在，但在第30天（幼崽自然断奶年龄）降至对照水平。通过移除幼崽诱导的过早断奶，使HMGCoA还原酶活性在2至4天内恢复正常。HMGCoA还原酶的升高并非由于该酶自然昼夜节律的消除或倒置，在哺乳期和对照动物中，其昼夜节律的相位相似，但幅度不同。哺乳期动物采食量增加可能导致了HMGCoA还原酶的增加，因为与未怀孕、未哺乳的对照大鼠配对饲养消除了哺乳期观察到的酶活性升高。然而，采食量增加并未诱导哺乳期大鼠HMGCoA还原酶升高，因为采食量的主要变化发生在酶活性最初增加之后。
